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Sunday, 3 August 2014

[S280.Ebook] Download Sample Size Calculations in Clinical Research, by Shein-Chung Chow, Jun Shao, Hansheng Wang

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Sample size calculation plays an important role in clinical research. It is not uncommon, however, to observe discrepancies among study objectives (or hypotheses), study design, statistical analysis (or test statistic), and sample size calculation. Focusing on sample size calculation for studies conducted during the various phases of clinical research and development, Sample Size Calculation in Clinical Research explores the causes of discrepancies and how to avoid them.

This volume provides formulas and procedures for determination of sample size required not only for testing equality, but also for testing non-inferiority/superiority, and equivalence (similarity) based on both untransformed (raw) data and log-transformed data under a parallel-group design or a crossover design with equal or unequal ratio of treatment allocations. It contains a comprehensive and unified presentation of statistical procedures for sample size calculation that are commonly employed at various phases of clinical development. Each chapter includes, whenever possible, real examples of clinical studies from therapeutic areas such as cardiovascular, central nervous system, anti-infective, oncology, and women's health to demonstrate the clinical and statistical concepts, interpretations, and their relationships and interactions.

The book highlights statistical procedures for sample size calculation and justification that are commonly employed in clinical research and development. It provides clear, illustrated explanations of how the derived formulas and/or statistical procedures can be used.

Sales Rank: #4004501 in eBooks
Published on: 2003-03-04
Released on: 2003-03-04
Format: Kindle eBook

Review
This well composed book … contains sample size formulas and examples. … [A] good reference book for researchers in clinical trials.
- Journal of Statistical Computation & Simulation, Vol. 74, No. 5, May 2004

The reference list contains details of an excellent collection of articles. The examples are clearly illustrated. This is a fascinating book, and applied statisticians, health and medical researchers will like it a lot. Statistical consultants will be fond of the book as a reference guide.
-Journal of Statistical Computation and Simulation, Vol. 75, No. 9, Sept 2005

Review
"This well composed book contains sample size formulas and examples. [A] good reference book for researchers in clinical trials." - Journal of Statistical Computation & Simulation, Vol. 74, No. 5, May 2004

Most helpful customer reviews

30 of 30 people found the following review helpful.
sample size an important aspect of trial design
By Michael R. Chernick
The authors of this book have a great deal of clinical trial experience in the pharmaceutical industry as well as strong academic backgrounds. For the clinical trial statistician there is now a rich supply of software products to aid in the determination of sample size for a variety of modeling situations. So knowing formulas is no longer important. What is important is to understand the basis for the formulas. This book provides the industrial perspective and the main fixed sample size designs. In this industry trials are constructed to show superiority, noninferiority and equivalence. These three distinct appoaches lead to different results because the null and alternative hypotheses change as you change your goal from superiority to equivalence.

This book makes that important distinction and is very scholarly, providing many of the relevant references. Although most clinical trials are still parallel design randomized controlled trials with fixed sample size, there are more and more trials that allow for sequential decisionmaking and hence the actual total sample size can be subject to randomness. The group sequential trials have been the most successful in this regard. But now there are also more flexible "adaptive designs" that are being used. For group sequential designs see the text by Jennison and Turnbull and for the adaptive designs Chow and Chang and a more recent applied text by Chang are very good sources of information. Software packages that are available to do group sequential and adaptive designs are East by Cytel, Seq+Trials by Insightful Corp., PASS by Number Crunchersand ADDPLAN by a German Company. Also statisticians like Mark Chang and Keaven Anderson have created their own routines for adaptive designs using the R programming language.

29 of 31 people found the following review helpful.
nice coverage of typical sample size problems in clinical trials
By Michael R. Chernick
This is the second edition of a very popular book on sample size estimation that is a valuable reference for any statistician in the industry. we all need to go through such expercises at the beginning of a trial as part of the protocol development.

One disappointment I have with the book is that it does not delineate new topics and other changes/additions from the first edition. Often this is covered by having two Prefaces, the original one from the first edition and a new one from the second edition. The authors unfortunately did not choose to do that. So an owner of the first edition would have to scan through both books to identify the changes.

Another disappointment is the lack of reference to any existing software to do sample size estimation and these days there are a lot of products available. The programs nQuery Advisor and Power and Precision handle equivalence, superiority and noninferiority problems for continuous data. They also provide approximate and exact methods for binomial data. Other packages such as StatXact handle sample size estimation for exact binomial tests as well as for Fisher's Exact test. PASS, S+SeqTrial and East are packages that provide the designs and sample size stopping rules for group sequential procedures and in some cases adaptive designs. Also with the development of version 9 of SAS comes the new procedures power and glmpower that do everything that nQuery can handle.

The value of the book is that it develops the methodology and therefore helps with the understanding of how and when to use the various procedures. Traditional tables that use to be important for sample size calculations are now obsolete given the availability of good software tools. Although the book goes to great lengths to cover almost any application. Most of these applications can be handled these days through the available software packages.

I can definitely recommend this book as a fine reference on sample size estimation for the wide range of trial applications. I would only try to encourage the authors to drop the use of tables and get up to date by recommending the appropriate software for the various applications.

0 of 0 people found the following review helpful.
Four Stars
By June E. Nezamis
Good reference

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Thursday, 31 July 2014

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Reading Across the Disciplines provides reading strategies for a variety of academic disciplines (more than any other available text), concise skill instruction, and extensive practice to improve college-level reading and thinking skills.

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Reading Across the Disciplines is organized into three parts for flexibility and ease-of-use. Part One presents a brief skill introduction (in handbook format) introducing students to essential vocabulary, comprehension, critical reading, and reading rate skills. Part Two has twelve chapters, each containing three readings representative of a different academic discipline.

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Sales Rank: #1019018 in Books
Published on: 2014-08-03
Original language: English
Number of items: 1
Dimensions: 9.00" h x .90" w x 7.30" l, .0 pounds
Binding: Paperback
704 pages

About the Author
Kathleen McWhorter (Ph.D. SUNY, Buffalo) is Professor of Humanities and Coordinator of Learning Skills at Niagara County Community College. In addition to her developmental writing series from Houghton Mifflin, McWhorter is the author of several successful reading and study skills texts from Longman including College Reading and Study Skills, Efficient and Flexible Reading, Academic Reading, and Guide to College Reading. Recently, Bedford Books also published a new title from McWhorter, Successful College Writing, for freshman composition courses.

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[P970.Ebook] Ebook Free Clocks in the Sky: The Story of Pulsars (Springer Praxis Books), by Geoff McNamara

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Pulsars are rapidly spinning neutron stars, the collapsed cores of once massive stars that ended their lives as supernova explosions.

In this book, Geoff McNamara explores the history, subsequent discovery and contemporary research into pulsar astronomy. The story of pulsars is brought right up to date with the announcement in 2006 of a new breed of pulsar, Rotating Radio Transients (RRATs), which emit short bursts of radio signals separated by long pauses. These may outnumber conventional radio pulsars by a ratio of four to one. Geoff McNamara ends by pointing out that, despite the enormous success of pulsar research in the second half of the twentieth century, the real discoveries are yet to be made including, perhaps, the detection of the hypothetical pulsar black hole binary system by the proposed Square Kilometre Array - the largest single radio telescope in the world.

Sales Rank: #3032294 in Books
Brand: Geoff McNamara
Published on: 2008-11-17
Original language: English
Number of items: 1
Dimensions: 9.53" h x .47" w x 6.69" l, .90 pounds
Binding: Paperback
190 pages

Features

ISBN13: 9780387765600
Condition: New
Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!

Review

From the reviews:

"McNamara … has produced a masterpiece of science writing. … he proceeds to provide vignettes of the key theoretical developments and observational discoveries over the last 75 years that establish pulsars as one of the most important fields in astronomy. … difficult topics such as relativistic effects are so well explained that casual readers will understand the basic principles. This book has … excellent writing, thorough attention to historical accuracy, and good science. This book is hard to put down! Summing Up: Essential. All levels/libraries." (T. D. Oswalt, Choice, Vol. 46 (9), May, 2009)

"The author begins with some background information on the life and death of stars, an introduction to the neutron that is essential, some comments on quasars … . There are now a number of different types of pulsar, some having been found in the most unlikely places, for instance globular pulsars, pulsars with planets, magnetars and multibeams. The presentation is never boring and manages to convey the continued excitement that identifies the subject. I can … recommend it." (Bill Barlow, Astronomy Now, September, 2009)

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0 of 0 people found the following review helpful.
All about Pulsrs and how to detect them.
By George M. Sawyer
Fascinating!! I have found this book extraordinarily interesting and informative. It is written so that someone, like me, that is pretty much ignorant of the subject can obtain an overview of the subject. It is written for people who relate to concepts and do not want to be burdened by equations. The historical information is of great interest; One might say that it goes from "In the beginning..." and leads us up to very recent happenings. For anyone who is even casually interested in the subject, I would highly recommend this book. George M. Sawyer, Caltech, 1951. I purchased this book about one year ago from Amazon, and it arrived in perfect condition.

0 of 0 people found the following review helpful.
Interesting book!
By S. R. Sinclair
This is a great introduction to the intriguing subject of pulsars. It is well written but understandable to the average reader. I used this book for a general college astronomy course and learned a lot.

4 of 4 people found the following review helpful.
Good Entry Level Science
By spin_glass
This is a good book for those who have an interest in this particular stellar pathology also if you enjoy the type of writer who informs via the anecdote you will again find this an entertaining way to learn. He for example explains through the words of Ms Jocelyn Bell her perspective on not being included in the Nobel Prize for the discovery of the pulsar and from my own point of veiw I was interested to learn of the radio interferometry experiments carried out here in post war Sydney. The book begins with the life cycles of stars that eventually become the subject of this book and then leads in to the link between the subatomic and the nature of the neuton star. I felt this section was a little confused but encourage the prospective reader to 'read on'. A few of the diagrams are misplaced and in one case i can recall, insufficient in regard to explanations. Closing chapters explore the subclasses of the Pulsar as well as the system PSR 1913+16 which became famous through it being a test bed for General Relativity and the subject of another book by McNamara, gravitational waves.
This book I hope will inspire readers to look further into the types and classifications of stars as well as the interesting behaviour that they exhibit.
McNamara's book is thouroughly researched and therefore a reliable book, which is not always the case with popular science.

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Wednesday, 30 July 2014

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Julian S. Hatcher one of the 20th century's most outstanding experts on guns. A standard reference book for shooters, gunsmiths, ballisticians, historians, hunters and collectors

Sales Rank: #1539227 in Books
Published on: 1996
Binding: Leather Bound
488 pages

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1 of 1 people found the following review helpful.
Hatcher's notebook
By Steve Adams
One of about a half a dozen MUST have books if you have firearms and hand load for them.

Steve Adams
AdamsQuailHunter on GunBroker & Ancientguns Forums

0 of 0 people found the following review helpful.
A must have book if you are seriously into arms ...
By Vic S. Shahid
A must have book if you are seriously into arms and ammo. Impressive amount of research done about a 100 years ago.

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Tuesday, 29 July 2014

[K743.Ebook] Ebook The Polaris System Development: Bureaucratic and Programmatic Success in Government, by Harvey M. Sapolsky

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Published on: 2013-10-01
Original language: English
Number of items: 1
Dimensions: 9.29" h x .87" w x 6.34" l, .0 pounds
Binding: Hardcover

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4 of 4 people found the following review helpful.
Exceptional review of large systems management
By drpeck@gorge.net
Excellent summary of how one of the largest systems development projects undertaken up to that point was brought to fruition. Comparable to "Managing Large Systems" in showing how to do it right, and the importance of a strong leader at the helm.

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Friday, 11 July 2014

[Z847.Ebook] Free Ebook Political Performance in Syria: From the Six-Day War to the Syrian Uprising (Studies in International Performance), by Edward Ziter

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Political Performance in Syria, charts the history of a theatre that has sought the expansion of civil society and imagined alternate political realities. In doing so, the manuscript situates the current use of performance and theatre by artists of the Syrian Revolution within a long history of political contestation.

Sales Rank: #1423366 in eBooks
Published on: 2014-11-04
Released on: 2014-11-04
Format: Kindle eBook

Review

“The book adequately documents performed passages that will be very familiar to those who grew up watching the collaborations of al-Maghut and Duraid Lahham. The book is clearly intended almost exclusively for the non-Arab theater artist or scholar. … This book will serve as an excellent introduction for theater scholars, particularly those seeking a working model for researching and writing about Arab culture.” (Samer Al-Saber, SCTIW Review, sctiw.org, February, 2016)

About the Author

Edward Ziter is Associate Professor of Theatre History and Chair of the Department of Drama at the Tisch School of the Arts, New York University, USA. He is author of The Orient on the Victorian Stage and articles in Theatre Research International, TDR, Theatre Journal, Theatre Survey, The Wordsworth Circle, and numerous anthologies.

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Thursday, 10 July 2014

[F876.Ebook] Free PDF Transit Maps of the World: Every Urban Train Map on Earth, by Mark Ovenden

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Sales Rank: #2920548 in Books
Published on: 2015-11-05
Original language: English
Dimensions: 9.37" h x .63" w x 10.87" l, 1.15 pounds
Binding: Paperback

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